Back to Search
Start Over
A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
- Source :
-
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2011 Jul; Vol. 68 (1), pp. 157-64. Date of Electronic Publication: 2010 Sep 22. - Publication Year :
- 2011
-
Abstract
- Purpose: Curcumin, a plant-derived natural polyphenol, could be a promising anti-cancer drug and shows synergic effects with cytotoxic agents. We evaluated the safety and feasibility of combination therapy using curcumin with gemcitabine-based chemotherapy.<br />Methods: Gemcitabine-resistant patients with pancreatic cancer received 8 g oral curcumin daily in combination with gemcitabine-based chemotherapy. The primary endpoint was safety for phase I and feasibility of oral curcumin for phase II study.<br />Results: Twenty-one patients were enrolled. No dose-limiting toxicities were observed in the phase I study and oral curcumin 8 g/day was selected as the recommended dose for the phase II study. No patients were withdrawn from this study because of the intolerability of curcumin, which met the primary endpoint of the phase II study, and the median compliance rate of oral curcumin was 100% (Range 79-100%). Median survival time after initiation of curcumin was 161 days (95% confidence interval 109-223 days) and 1-year survival rate was 19% (4.4-41.4%). Plasma curcumin levels ranged from 29 to 412 ng/ml in five patients tested.<br />Conclusions: Combination therapy using 8 g oral curcumin daily with gemcitabine-based chemotherapy was safe and feasible in patients with pancreatic cancer and warrants further investigation into its efficacy.
- Subjects :
- Adenocarcinoma mortality
Adenocarcinoma physiopathology
Aged
Antineoplastic Agents adverse effects
Antineoplastic Agents blood
Antineoplastic Agents pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols adverse effects
Curcumin adverse effects
Curcumin pharmacokinetics
Deoxycytidine administration & dosage
Deoxycytidine adverse effects
Drug Combinations
Drug Synergism
Female
Humans
Male
Medication Adherence
Middle Aged
Oxonic Acid adverse effects
Pancreatic Neoplasms mortality
Pancreatic Neoplasms physiopathology
Survival Rate
Tegafur adverse effects
Gemcitabine
Adenocarcinoma drug therapy
Antineoplastic Agents administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Curcumin administration & dosage
Deoxycytidine analogs & derivatives
Drug Resistance, Neoplasm
Oxonic Acid therapeutic use
Pancreatic Neoplasms drug therapy
Tegafur therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0843
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer chemotherapy and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20859741
- Full Text :
- https://doi.org/10.1007/s00280-010-1470-2