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Clinical and laboratory aspects of Ro/SSA-52 autoantibodies.
- Source :
-
Autoimmunity reviews [Autoimmun Rev] 2011 Jan; Vol. 10 (3), pp. 150-4. Date of Electronic Publication: 2010 Sep 18. - Publication Year :
- 2011
-
Abstract
- Anti-Ro/SSA antibodies, which were described for the first time in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS), are the most prevalent extractable nuclear antigen (ENA) specificity identified in laboratories. Two types of anti-Ro/SSA antibodies have been described, anti-SSA-52 kDa (aSSA52) and anti-SSA-60 kDa (aSSA60), each specific to different antigens. Anti-Ro/SSA52 autoantibodies are more frequent than other autoantibodies possibly because of the antigen's accessible and ubiquitous nature. The sites involved and the symptoms associated with these autoantibodies depend on the antigen's structural variability. Isolated congenital complete atrioventricular block (CAVB) shows a close association with maternal anti-Ro/SSA and anti-La/SSB antibodies; the highest relative risks of CAVB are seen in offspring of mothers with antibodies against 52-kDa Ro and 48-kDa La proteins. Anti-Ro/SSA52 antibodies have little impact on adult rheumatic autoimmune diseases or adult cardiac arrhythmias, but the course of autoimmune liver diseases is greatly worsened by their presence, and solid tumours tend to relapse. Their diagnostic role in rheumatic diseases is controversial, although a significant association between isolated anti-Ro/SSA52-kDa positivity and myositis and to a lesser extent with systemic sclerosis (SSc) has been described. However, the majority of the specific diagnosis is mostly based on the simultaneous presence of other autoantibodies that seems diagnostically more relevant.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Animals
Atrioventricular Block blood
Atrioventricular Block congenital
Atrioventricular Block diagnosis
Atrioventricular Block immunology
Autoantibodies blood
Female
Fetomaternal Transfusion blood
Fetomaternal Transfusion diagnosis
Fetomaternal Transfusion immunology
Humans
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic diagnosis
Lupus Erythematosus, Systemic immunology
Male
Myositis blood
Myositis diagnosis
Myositis immunology
Pregnancy
Ribonucleoproteins blood
Scleroderma, Systemic blood
Scleroderma, Systemic diagnosis
Scleroderma, Systemic immunology
Sjogren's Syndrome blood
Sjogren's Syndrome diagnosis
Sjogren's Syndrome immunology
Antibody Specificity immunology
Autoantibodies immunology
Ribonucleoproteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0183
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Autoimmunity reviews
- Publication Type :
- Academic Journal
- Accession number :
- 20854935
- Full Text :
- https://doi.org/10.1016/j.autrev.2010.09.005