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HTLV-2b among HIV type 1-coinfected injecting drug users in Spain.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2011 May; Vol. 27 (5), pp. 579-83. Date of Electronic Publication: 2010 Nov 23. - Publication Year :
- 2011
-
Abstract
- Human T cell lymphotropic virus type 2 (HTLV-2) infection is endemic in the American Indian population and Pygmy tribes in Africa. Nevertheless, HTLV-2 infection has been predominantly detected in U.S. and European injecting drug users (IDU). Noteworthy is that the HTLV-2a subtype is the main circulating variant in North America and Eastern Europe whereas the HTLV-2b subtype is mainly found in Western Europe, particularly in Italy and Spain where coinfection with HIV-1 is frequent. Twelve Spanish subjects infected with HTLV-2 were recruited for the study. All of them were IDUs coinfected with HIV-1. Molecular epidemiology was done by sequencing the LTR, env, and tax regions and by generating phylogenetic trees. The present study showed that all the sequences belonged to the HTLV-2b subtype and were closely related to other Spanish and Portuguese reported sequences, clearly differentiated from those belonging to the HTLV-2a subtype from Eastern Europe. Therefore, infection with HTLV-2b remains prevalent in Spain based on previous studies.
- Subjects :
- Cluster Analysis
Genes, pX
HIV-1 isolation & purification
Human T-lymphotropic virus 2 genetics
Humans
Molecular Epidemiology
Molecular Sequence Data
RNA, Viral genetics
Sequence Analysis, DNA
Sequence Homology
Spain
Terminal Repeat Sequences genetics
Viral Envelope Proteins genetics
HIV Infections complications
HTLV-II Infections complications
HTLV-II Infections virology
Human T-lymphotropic virus 2 isolation & purification
Substance Abuse, Intravenous complications
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8405
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 20854172
- Full Text :
- https://doi.org/10.1089/AID.2010.0263