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Umbilical cord blood stem cells: what to expect.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2010 Sep; Vol. 1205, pp. 17-22. - Publication Year :
- 2010
-
Abstract
- Umbilical cord blood (UCB) is a valuable alternative source of hematopoietic stem cells (HSCs). It has unique advantages of easy procurement, absence of risk to donors, low risk of transmitting infections, immediate availability, greater tolerance of human leukocyte antigen (HLA) disparity, and lower incidence of inducing severe graft-versus-host disease (GVHD). In the last several years, these features of UCB permit the field of UCB transplantation (UCBT) to move at a faster pace for both children and adults with malignancies and nonmalignancies. However, new strategies and novel developments are expected to improve engraftment and reconstitution, and to enable in utero transplantation for early therapy, as well as to allow the therapy for a wide spectrum of human diseases.<br /> (© 2010 New York Academy of Sciences.)
- Subjects :
- Adult
Animals
Cord Blood Stem Cell Transplantation methods
Cord Blood Stem Cell Transplantation statistics & numerical data
Fetal Blood physiology
Hematologic Neoplasms therapy
Humans
Immunologic Deficiency Syndromes therapy
Metabolic Diseases therapy
Cord Blood Stem Cell Transplantation trends
Fetal Blood cytology
Hematopoietic Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1205
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 20840248
- Full Text :
- https://doi.org/10.1111/j.1749-6632.2010.05659.x