Highly efficient synthesis of 3-amino-/alkylthio-cyclobut-2-en-1-ones based on the cyclization of acyl ketene dithioacetals.

Authors :: Zhao YL
Yang SC
Di CH
Han XD
Liu Q
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Oct 28; Vol. 46 (40), pp. 7614-6. Date of Electronic Publication: 2010 Sep 13.
Publication Year :: 2010
Abstract: A new strategy for the highly efficient one-pot synthesis of 3-amino-/alkylthio-cyclobut-2-en-1-ones based on the cyclization of acyl ketene dithioacetals is disclosed. In addition, the rearrangement of 3-amino-cyclobut-2-en-1-ones to 4-quinolone derivatives is described.

Subjects :: 4-Quinolones chemistry
Acetals chemical synthesis
Amines chemical synthesis
Cyclization
Cyclobutanes chemistry
Sulfhydryl Compounds chemical synthesis
4-Quinolones chemical synthesis
Acetals chemistry
Amines chemistry
Cyclobutanes chemical synthesis
Sulfhydryl Compounds chemistry

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