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The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia.
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2011 Aug; Vol. 27 (8), pp. 587-92. Date of Electronic Publication: 2010 Sep 14. - Publication Year :
- 2011
-
Abstract
- Objective: To assess the impact of metformin and of two different oral contraceptives (OCs) containing cyproterone acetate and drospirenone, on serum anti-Müllerian hormone (AMH) levels, in a cohort of women with polycystic ovary syndrome (PCOS) with hyperandrogenism.<br />Design: Prospective randomised study.<br />Setting: Division of Endocrinology and Human Reproduction, Aristotle University of Thessaloniki.<br />Patients: Forty-five (45) women with PCOS diagnosed according to the criteria proposed in 1990 by the NIH.<br />Interventions: Women with PCOS were randomised into three groups, all treated for 6 months: Group A received an OC containing 35 μg ethinylestradiol plus 2 mg cyproterone acetate, Group B received an OC containing 30 μg ethinylestradiol plus 3 mg drospirenone and Group C received metformin 850 mg × 2. Main outcome measure(s). Anti-Müllerian hormone levels were measured by a specific ELISA.<br />Results: AMH was significantly decreased under treatment with 35 μg ethinylestradiol plus 2 mg cyproterone acetate (p = 0.002 at 3 months and p < 0.001 at 6 months). Treatment with 30 μg ethinylestradiol plus 3 mg drospirenone, and treatment with metformin 850 mg × 2 did not significantly affect serum AMH levels. AMH was significantly decreased under OCs treatment compared to metformin 850 mg × 2 (p = 0.005).<br />Conclusion(s): AMH serum levels were significantly decreased under treatment with 35 μg ethinylestradiol plus 2 mg cyproterone acetate, due to decrease in androgens and suppression of gonadotropins.
- Subjects :
- Adolescent
Adult
Androgen Antagonists adverse effects
Androgen Antagonists therapeutic use
Androstenes adverse effects
Androstenes therapeutic use
Blood Glucose analysis
Body Mass Index
Cohort Studies
Contraceptives, Oral, Combined adverse effects
Cyproterone Acetate adverse effects
Cyproterone Acetate therapeutic use
Drug Combinations
Ethinyl Estradiol adverse effects
Ethinyl Estradiol therapeutic use
Female
Humans
Insulin Resistance
Polycystic Ovary Syndrome diagnosis
Polycystic Ovary Syndrome physiopathology
Practice Guidelines as Topic
Young Adult
Anti-Mullerian Hormone blood
Contraceptives, Oral, Combined therapeutic use
Hyperandrogenism etiology
Hypoglycemic Agents therapeutic use
Metformin therapeutic use
Polycystic Ovary Syndrome blood
Polycystic Ovary Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 27
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 20836726
- Full Text :
- https://doi.org/10.3109/09513590.2010.507283