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[Unspecific effects of certain siRNA molecules used in the treatment of age related macular degeneration].
- Source :
-
Ugeskrift for laeger [Ugeskr Laeger] 2010 Sep 06; Vol. 172 (36), pp. 2457-9. - Publication Year :
- 2010
-
Abstract
- In clinical trials on age-related macular degeneration, small interfering RNAs (siRNAs) targeting vascular endothelial growth factor or its receptor are used to inhibit angiogenesis. However, novel data suggests that certain siRNA molecules can act unspecifically, without even entering a cell. The sequence- and target-independent suppression of the angiogenesis seems to be mediated via extracellular binding to the toll-like receptors TLR3.
- Subjects :
- Antibodies, Monoclonal, Humanized
Genetic Therapy methods
Humans
Macular Degeneration genetics
Macular Degeneration therapy
Ranibizumab
Toll-Like Receptor 3 genetics
Toll-Like Receptor 3 metabolism
Vascular Endothelial Growth Factor A antagonists & inhibitors
Vascular Endothelial Growth Factor A genetics
Angiogenesis Inhibitors therapeutic use
Antibodies, Monoclonal therapeutic use
Macular Degeneration drug therapy
RNA, Small Interfering genetics
RNA, Small Interfering metabolism
Subjects
Details
- Language :
- Danish
- ISSN :
- 1603-6824
- Volume :
- 172
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Ugeskrift for laeger
- Publication Type :
- Academic Journal
- Accession number :
- 20825735