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[Persistence of the influenza virus in children with congenital CNS pathology].
- Source :
-
Voprosy virusologii [Vopr Virusol] 1990 Nov-Dec; Vol. 35 (6), pp. 452-6. - Publication Year :
- 1990
-
Abstract
- Sick infants born to mothers who experienced influenza during pregnancy were examined. The cerebrospinal fluid, serum and blood cells were collected from such children with signs of congenital immune deficiency and progressive pathology of the central nervous system. None of the specimens yielded infectious influenza virus, but by means of molecular hybridization virus-specific genetic sequences were found in small amounts in the cerebrospinal fluid and serum and in high concentrations in blood cells. Persistence of genes NP, M and H1 of influenza A/H1N1 virus was observed in the blood cells of one infant for 83 days (the observation period). At the same time, the lack of antibodies to viral M protein in serum of this baby was demonstrated by the immune blotting method.
- Subjects :
- Antibodies, Viral blood
Central Nervous System Diseases congenital
Central Nervous System Diseases immunology
Child, Preschool
DNA, Viral analysis
DNA, Viral genetics
Female
Genes, Viral genetics
Humans
Infant
Infant, Newborn
Influenza A virus genetics
Influenza A virus immunology
Influenza, Human microbiology
Male
Nucleic Acid Hybridization
Pregnancy
Pregnancy Complications, Infectious microbiology
RNA, Viral analysis
RNA, Viral genetics
Central Nervous System Diseases microbiology
Influenza A virus isolation & purification
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-4088
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Voprosy virusologii
- Publication Type :
- Academic Journal
- Accession number :
- 2082545