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Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma.
- Source :
-
Cancer science [Cancer Sci] 2010 Dec; Vol. 101 (12), pp. 2664-9. Date of Electronic Publication: 2010 Sep 01. - Publication Year :
- 2010
-
Abstract
- Epigenetic alterations play an important role in carcinogenesis. Recent studies have suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Global histone acetylation levels (histone H3 lysine 9 acetylation [H3K9Ac], histone H3 lysine 18 acetylation [H3K18Ac], total histone H3 acetylation [H3Ac] and total histone H4 acetylation [H4Ac]) were determined in patients with renal cell carcinoma (RCC) using immunohistochemistry in a tissue micro array with 193 RCC and 10 oncocytoma specimens. The histone acetylation pattern was not different among the diverse histological subtypes of RCC or oncocytoma samples. The H3Ac levels were inversely correlated with pT-stage (P = 0.005), distant metastasis (P = 0.036), Fuhrman grading (P = 0.001) and RCC progression (P = 0.029, hazard ratio 0.87). H4Ac deacetylation was correlated with pT-stage (P = 0.011) and grading (P = 0.029). H3K18Ac levels were an independent predictor of cancer-progression following surgery for localized RCC in the univariate (P = 0.001, hazard ratio 0.78) and multivariate (P = 0.005, hazard ratio 0.82) analysis. In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC.<br /> (© 2010 Japanese Cancer Association.)
- Subjects :
- Acetylation
Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell mortality
Carcinoma, Renal Cell pathology
Female
Histones genetics
Humans
Immunohistochemistry
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Tissue Array Analysis
Carcinoma, Renal Cell genetics
Epigenesis, Genetic
Histones metabolism
Kidney Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7006
- Volume :
- 101
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 20825416
- Full Text :
- https://doi.org/10.1111/j.1349-7006.2010.01717.x