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Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat.

Authors :
Day JR
Laping NJ
McNeill TH
Schreiber SS
Pasinetti G
Finch CE
Source :
Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 1990 Dec; Vol. 4 (12), pp. 1995-2002.
Publication Year :
1990

Abstract

This study concerns effects of the testes on two macromolecules in the rat hippocampus that were previously not known to be responsive to this endocrine axis. Castration for 3 weeks elevated the expression of glial fibrillary acidic protein (GFAP) and sulfated glycoprotein-2 (SGP-2) in male rat hippocampus, as shown by Northern blots and immunocytochemistry. SGP-2 mRNA was colocalized with GFAP, implying increased prevalence in astrocytes after castration. During hippocampal responses to deafferentation by entorhinal cortex lesions that damage the perforant path and induce synaptic reorganization, both mRNA and protein for SGP-2 and GFAP increase. Moreover, prior castration had an additive effect with entorhinal cortex lesions in the increase in GFAP and SGP-2 mRNA. These data suggest that testicular hormones regulate hippocampal astrocyte activity in intact adult rats as well as during synaptic reorganization in response to deafferenting lesions.

Details

Language :
English
ISSN :
0888-8809
Volume :
4
Issue :
12
Database :
MEDLINE
Journal :
Molecular endocrinology (Baltimore, Md.)
Publication Type :
Academic Journal
Accession number :
2082194
Full Text :
https://doi.org/10.1210/mend-4-12-1995