Back to Search
Start Over
Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence.
- Source :
-
Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2010 Dec; Vol. 13 (4), pp. 311-5. Date of Electronic Publication: 2010 Sep 07. - Publication Year :
- 2010
-
Abstract
- Alterations of chromosome 8, including amplification at 8q24 harboring the C-MYC oncogene, have been noted as one of the most common chromosomal abnormalities in prostate cancer (CaP) progression. However, the frequency of C-MYC alterations in CaP has remained uncertain. A recent study, using a new anti-MYC antibody, described prevalent upregulation of nuclear C-MYC protein expression as an early oncogenic alteration in CaP. Further, we have recently reported regulation of C-MYC expression by ERG and a significant correlation between C-MYC overexpression and TMPRSS2-ERG fusion in early stage CaP. These emerging data suggest that increased C-MYC expression may be a critical and early oncogenic event driving CaP progression. In this study, we assessed whether C-MYC mRNA overexpression in primary prostate tumors was predictive of more aggressive tumor or disease progression. Our approach was to quantitatively determine C-MYC mRNA expression levels in laser capture micro-dissected tumor cells and matched benign epithelial cells in a radical prostatectomy cohort with long follow-up data available. On the basis of our results, we conclude that elevated C-MYC expression in primary prostate tumor is biologically relevant and may be a predictor of future biochemical recurrence.
- Subjects :
- Adenocarcinoma mortality
Adenocarcinoma pathology
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Gene Expression Regulation, Neoplastic
Humans
Male
Oncogenes genetics
Prognosis
Prostatic Neoplasms mortality
Prostatic Neoplasms pathology
Proto-Oncogene Proteins c-myc genetics
Proto-Oncogene Proteins c-myc metabolism
RNA, Messenger analysis
RNA, Messenger metabolism
Recurrence
Survival Analysis
Up-Regulation genetics
Adenocarcinoma diagnosis
Adenocarcinoma genetics
Genes, myc
Prostatic Neoplasms diagnosis
Prostatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5608
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Prostate cancer and prostatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20820186
- Full Text :
- https://doi.org/10.1038/pcan.2010.31