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Evaluation of a novel isotope biomarker for dietary consumption of sweets.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2010 Nov 01; Vol. 172 (9), pp. 1045-52. Date of Electronic Publication: 2010 Sep 03. - Publication Year :
- 2010
-
Abstract
- Carbon isotopic signatures ("δ¹³C") might reflect consumption of corn- and cane-based sweeteners. The authors hypothesized that the δ¹³C value of human serum is higher for individuals with high versus low intakes of corn- and cane-based sweeteners (measured as sweetened beverage intake). They conducted a cross-sectional study within the Atherosclerosis Risk in Communities Magnetic Resonance Imaging study (Maryland, 2005-2006). Diet was assessed by food frequency questionnaire, and blinded serum samples were assayed by natural abundance stable isotope mass spectroscopy. Studied were 186 participants (53% male; mean age, 71 years; mean body mass index, 30 kg/m²). Serum δ¹³C values for individuals with high sweetened beverage intakes were significantly higher than for those with low intakes (-19.15‰ vs. -19.47‰, P < 0.001). Serum δ¹³C value increased 0.20‰ for every serving/day of sweetened beverages (P < 0.01). The association between sweetened beverages and serum δ¹³C value remained significant after adjustment for confounding by corn-based product intake (P < 0.001). Serum δ¹³C values were also associated with waist circumference, body mass index, and waist-to-hip ratio. This study provides the first known evidence that the δ¹³C value of human serum differs between persons consuming low and high amounts of sweets. Within the proper framework, serum δ¹³C value could be developed into an objective biomarker promoting more reliable assessment of dietary sweets intake.
- Subjects :
- Aged
Aged, 80 and over
Algorithms
Beverages statistics & numerical data
Biomarkers blood
Body Mass Index
Cross-Sectional Studies
Diet Surveys
District of Columbia epidemiology
Energy Intake
Female
Food Analysis methods
Food Preferences
Humans
Male
Maryland epidemiology
Middle Aged
Nutrition Assessment
Obesity blood
Obesity etiology
Surveys and Questionnaires
Waist Circumference
Waist-Hip Ratio
Atherosclerosis blood
Body Weight
Carbon Isotopes
Dietary Sucrose blood
Obesity prevention & control
Sweetening Agents
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 172
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 20817784
- Full Text :
- https://doi.org/10.1093/aje/kwq247