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The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus.
- Source :
-
Current cardiology reports [Curr Cardiol Rep] 2010 Nov; Vol. 12 (6), pp. 464-71. - Publication Year :
- 2010
-
Abstract
- Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease (CVD) morbidity and mortality worldwide. Renin-angiotensin system (RAS) blockers have been indispensable in diminishing the macrovascular and microvascular complications of diabetes. In addition, cumulative evidence from retrospective studies pointed toward a beneficial effect of RAS agents in preventing the development and progression of T2DM. This disease-modifying potential of RAS blockers has been substantiated by recent prospective trials. Contemporary concepts regarding the natural history of T2DM and the pathophysiologic processes involved have increased our understanding of the mechanisms underlying the therapeutic potential of these agents in diabetes management. In addition to their established roles in the primary prevention of CVD in patients with diabetes, RAS blockers might be considered a suitable therapeutic choice for preventing the development of frank diabetes in high-risk patients.
- Subjects :
- Angiotensin II Type 1 Receptor Blockers pharmacology
Angiotensin-Converting Enzyme Inhibitors pharmacology
Antihypertensive Agents therapeutic use
Blood Glucose metabolism
Cardiovascular Diseases etiology
Cardiovascular Diseases prevention & control
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 etiology
Disease Progression
Humans
Insulin Resistance
Microvessels
Risk Factors
Signal Transduction
Angiotensin II Type 1 Receptor Blockers therapeutic use
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Cardiovascular Diseases drug therapy
Diabetes Mellitus, Type 2 prevention & control
Diabetic Angiopathies prevention & control
Renin-Angiotensin System drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1534-3170
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current cardiology reports
- Publication Type :
- Academic Journal
- Accession number :
- 20809236
- Full Text :
- https://doi.org/10.1007/s11886-010-0138-1