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The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus.

Authors :
Lardizabal JA
Deedwania PC
Source :
Current cardiology reports [Curr Cardiol Rep] 2010 Nov; Vol. 12 (6), pp. 464-71.
Publication Year :
2010

Abstract

Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease (CVD) morbidity and mortality worldwide. Renin-angiotensin system (RAS) blockers have been indispensable in diminishing the macrovascular and microvascular complications of diabetes. In addition, cumulative evidence from retrospective studies pointed toward a beneficial effect of RAS agents in preventing the development and progression of T2DM. This disease-modifying potential of RAS blockers has been substantiated by recent prospective trials. Contemporary concepts regarding the natural history of T2DM and the pathophysiologic processes involved have increased our understanding of the mechanisms underlying the therapeutic potential of these agents in diabetes management. In addition to their established roles in the primary prevention of CVD in patients with diabetes, RAS blockers might be considered a suitable therapeutic choice for preventing the development of frank diabetes in high-risk patients.

Details

Language :
English
ISSN :
1534-3170
Volume :
12
Issue :
6
Database :
MEDLINE
Journal :
Current cardiology reports
Publication Type :
Academic Journal
Accession number :
20809236
Full Text :
https://doi.org/10.1007/s11886-010-0138-1