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Spatial organization acts on cell signaling: how physical force contributes to the development of cancer.

Spatial organization acts on cell signaling: how physical force contributes to the development of cancer.

Authors :
Plodinec M
Schoenenberger CA
Source :
Breast cancer research : BCR [Breast Cancer Res] 2010; Vol. 12 (4), pp. 308. Date of Electronic Publication: 2010 Aug 23.
Publication Year :
2010

Abstract

Cells constantly encounter physical forces and respond to neighbors and circulating factors by triggering intracellular signaling cascades that in turn affect their behavior. The mechanisms by which cells transduce mechanical signals to downstream biochemical changes are not well understood. In their work, Salaita and coworkers show that the spatial organization of cell surface receptors is crucial for mechanotransduction. Consequently, force modulation that disrupts the mechanochemical coupling may represent a critical step in cancerogenesis.

Details

Language :
English
ISSN :
1465-542X
Volume :
12
Issue :
4
Database :
MEDLINE
Journal :
Breast cancer research : BCR
Publication Type :
Academic Journal
Accession number :
20804566
Full Text :
https://doi.org/10.1186/bcr2623