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Spatial organization acts on cell signaling: how physical force contributes to the development of cancer.
Spatial organization acts on cell signaling: how physical force contributes to the development of cancer.
- Source :
-
Breast cancer research : BCR [Breast Cancer Res] 2010; Vol. 12 (4), pp. 308. Date of Electronic Publication: 2010 Aug 23. - Publication Year :
- 2010
-
Abstract
- Cells constantly encounter physical forces and respond to neighbors and circulating factors by triggering intracellular signaling cascades that in turn affect their behavior. The mechanisms by which cells transduce mechanical signals to downstream biochemical changes are not well understood. In their work, Salaita and coworkers show that the spatial organization of cell surface receptors is crucial for mechanotransduction. Consequently, force modulation that disrupts the mechanochemical coupling may represent a critical step in cancerogenesis.
- Subjects :
- Actomyosin physiology
Breast Neoplasms metabolism
Breast Neoplasms pathology
Cell Line, Tumor
Cell Shape physiology
Ephrin-A1 metabolism
Female
Humans
Protein Binding
Receptor, EphA2 metabolism
Breast Neoplasms physiopathology
Mechanotransduction, Cellular physiology
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-542X
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Breast cancer research : BCR
- Publication Type :
- Academic Journal
- Accession number :
- 20804566
- Full Text :
- https://doi.org/10.1186/bcr2623