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Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2010 Oct 01; Vol. 185 (7), pp. 3824-8. Date of Electronic Publication: 2010 Aug 27. - Publication Year :
- 2010
-
Abstract
- T cell receptor activation inhibits expression of the E74-like factor (ELF) 4 and Krüppel-like factor 4 genes to release naive CD8(+) T cells from their quiescent state. In this study, we show that ELF4 controls the ERK-mediated proliferative response by maintaining normal levels of dual-specificity phosphatases 1 and 5 in CD8(+) T cells. In activated CD8(+) T cells, the mammalian target of rapamycin pathway inhibits ELF4 and Krüppel-like factor 4 expression downstream of ERK and PI3K signaling. Our findings demonstrate that rapamycin could be used to modulate expression of this transcriptional network involved in cell-cycle regulation.
- Subjects :
- Animals
CD8-Positive T-Lymphocytes immunology
DNA-Binding Proteins immunology
Gene Expression
Immunoblotting
Intracellular Signaling Peptides and Proteins immunology
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors immunology
Kruppel-Like Transcription Factors metabolism
Mice
Protein Serine-Threonine Kinases immunology
Reverse Transcriptase Polymerase Chain Reaction
TOR Serine-Threonine Kinases
Transcription Factors immunology
CD8-Positive T-Lymphocytes metabolism
DNA-Binding Proteins metabolism
Gene Expression Regulation immunology
Intracellular Signaling Peptides and Proteins metabolism
Lymphocyte Activation immunology
Protein Serine-Threonine Kinases metabolism
Signal Transduction immunology
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 185
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 20802152
- Full Text :
- https://doi.org/10.4049/jimmunol.1000718