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Stem cell technology for the treatment of acute and chronic renal failure.
- Source :
-
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2010 Sep; Vol. 156 (3), pp. 161-8. Date of Electronic Publication: 2010 Jul 30. - Publication Year :
- 2010
-
Abstract
- Acute and chronic renal failure are disorders with high rates of morbidity and mortality. Current treatment is based upon conventional dialysis to provide volume regulation and small solute clearance. There is growing recognition that renal failure is a complex disease state requiring a multifactorial therapy to address the short-comings of the conventional monofactorial approach. Kidney transplantation remains the most effective treatment, however, organ availability lags far behind demand. Many key kidney functions including gluconeogenesis, ammoniagenesis, metabolism of glutathione, catabolism of important peptide hormones, growth factors, and cytokines critical to multiorgan homeostasis and immunomodulation are provided by renal tubule cells. Therefore, cell-based therapies are promising multifactorial treatment approaches. In this review, current stem cell technologies including adult stem cells, embryonic stem cells and induced pluripotent stem cells will be discussed as cell sources for the treatment of acute and chronic renal failure.<br /> (Copyright 2010 Mosby, Inc. All rights reserved.)
- Subjects :
- Acute Kidney Injury therapy
Adult
Cell Differentiation
Embryonic Stem Cells transplantation
Hemofiltration methods
Homeostasis
Humans
Kidney cytology
Kidney pathology
Kidney physiology
Kidney Failure, Chronic therapy
Kidney Tubules physiology
Kidneys, Artificial
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells cytology
Morphogenesis
Renal Replacement Therapy methods
Ureter physiology
Ureter physiopathology
Acute Kidney Injury surgery
Kidney Failure, Chronic surgery
Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1810
- Volume :
- 156
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Translational research : the journal of laboratory and clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20801413
- Full Text :
- https://doi.org/10.1016/j.trsl.2010.07.005