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[Functional imaging of deep brain stimulation in idiopathic Parkinson's disease].
- Source :
-
Der Nervenarzt [Nervenarzt] 2010 Oct; Vol. 81 (10), pp. 1204-7. - Publication Year :
- 2010
-
Abstract
- Functional brain imaging allows the effects of deep brain stimulation (DBS) on the living human brain to be investigated. In patients with advanced Parkinson's disease (PD), positron emission tomography (PET) studies were undertaken at rest as well as under motor, cognitive or behavioral activation. DBS leads to a reduction of abnormal PD-related network activity in the motor system, which partly correlates with the improvement of motor symptoms. The local increase of energy consumption within the direct target area suggests a predominant excitatory influence of the stimulation current on neuronal tissue. Remote effects of DBS of the subthalamic nucleus (STN) on frontal association cortices indicate an interference of stimulation energy with associative and limbic basal ganglia loops. Taken together, functional brain imaging provides very valuable data for advancement of the DBS technique in PD therapy.
- Subjects :
- Affect physiology
Basal Ganglia diagnostic imaging
Basal Ganglia physiopathology
Brain Mapping
Cognition physiology
Dopamine metabolism
Fluorodeoxyglucose F18
Frontal Lobe diagnostic imaging
Frontal Lobe physiopathology
Humans
Limbic System diagnostic imaging
Limbic System physiopathology
Nerve Net diagnostic imaging
Nerve Net physiopathology
Neurons diagnostic imaging
Neurons physiology
Neuropsychological Tests
Subthalamic Nucleus diagnostic imaging
Subthalamic Nucleus physiopathology
Verbal Behavior physiology
Brain diagnostic imaging
Brain physiopathology
Deep Brain Stimulation
Image Processing, Computer-Assisted methods
Imaging, Three-Dimensional methods
Parkinson Disease diagnostic imaging
Parkinson Disease physiopathology
Positron-Emission Tomography methods
Subjects
Details
- Language :
- German
- ISSN :
- 1433-0407
- Volume :
- 81
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Der Nervenarzt
- Publication Type :
- Academic Journal
- Accession number :
- 20798917
- Full Text :
- https://doi.org/10.1007/s00115-010-3027-3