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The use of cell-delivered gene therapy for the treatment of HIV/AIDS.
- Source :
-
Immunologic research [Immunol Res] 2010 Dec; Vol. 48 (1-3), pp. 84-98. - Publication Year :
- 2010
-
Abstract
- HIV/AIDS is a disease that impairs immune function, primarily by decreasing T-lymphocyte count. Its progression can be contained by highly active antiretroviral therapy (HAART), but there are side effects that can be severe, and the development of resistance often forces the physician to modify the HAART regimen. There are no vaccines available for HIV. An alternative approach that could provide a path to a curative therapy is the use of cell-delivered gene therapy in which an anti-HIV gene(s) is introduced into hematopoietic cells to produce a population that is protected from the effects of HIV. In this paper, we review the field and discuss an approach using a short hairpin RNA to CCR5, an important co-receptor for HIV.
- Subjects :
- Animals
Clinical Trials as Topic
Disease Models, Animal
Genes, Viral genetics
Genetic Therapy trends
HIV pathogenicity
HIV Infections genetics
HIV Infections immunology
Hematopoietic Stem Cells pathology
Humans
Mice
RNA, Small Interfering genetics
Receptors, CCR5 genetics
Receptors, HIV genetics
Virus Replication genetics
HIV physiology
HIV Infections therapy
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells metabolism
RNA, Small Interfering therapeutic use
Receptors, CCR5 metabolism
Receptors, HIV metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0755
- Volume :
- 48
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Immunologic research
- Publication Type :
- Academic Journal
- Accession number :
- 20737298
- Full Text :
- https://doi.org/10.1007/s12026-010-8169-7