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The value of apelin-36 and brain natriuretic peptide measurements in patients with first ST-elevation myocardial infarction.
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2010 Dec 14; Vol. 411 (23-24), pp. 2014-8. Date of Electronic Publication: 2010 Aug 22. - Publication Year :
- 2010
-
Abstract
- Background: We aimed to assess apelin-novel endogenous ligand for the angiotensin-like 1 receptor in patients with ST-elevation myocardial infarction (STEMI) and to compare its value with B-type natriuretic peptide (BNP).<br />Methods: In 78 consecutive patients with first STEMI treated with primary PCI, plasma apelin-36 (RIA) and BNP (MEIA) concentrations were measured twice: on admission and on the fifth day of hospitalization. Left ventricle ejection fraction (LVEF) was assessed on admission and composite endpoint (CEP)-after 1 year follow-up.<br />Results: During the 5-day interval median plasma BNP level significantly increased and median plasma apelin concentration significantly decreased. BNP, but not apelin, correlated with low LVEF (<50%). In ROC analysis only BNP measurements were diagnostic for low LVEF. In ANOVA test, in patients with CEP, a significant decrease in apelin (but not BNP) concentrations measured in 5-day interval was found. ROC analysis identified only second BNP measurement as significant to estimate adverse outcome 0.627 in the prediction of CEP (95% confidence interval=0.507-0.736).<br />Conclusion: Following STEMI there is a decrease of plasma apelin-36 concentration and an increase of plasma BNP concentration. BNP is better, than apelin diagnostic value for the detection of impaired LVEF. Both BNP and apelin have prognostic value, although both needs further evaluation.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Apelin
Female
Humans
Male
Middle Aged
Myocardial Infarction diagnosis
Myocardial Infarction therapy
Prognosis
Stroke Volume
Ventricular Dysfunction, Left blood
Ventricular Dysfunction, Left metabolism
Intercellular Signaling Peptides and Proteins blood
Myocardial Infarction blood
Myocardial Infarction metabolism
Natriuretic Peptide, Brain blood
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3492
- Volume :
- 411
- Issue :
- 23-24
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20736001
- Full Text :
- https://doi.org/10.1016/j.cca.2010.08.024