[Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow].

Authors :: Bondarenko EA
Tupitsyna TV
Slominskiĭ PA
Shetova IM
Shamalov NA
Botsina AIu
Skvortsova VI
Limborskaia SA
Source :: Genetika [Genetika] 2010 Jun; Vol. 46 (6), pp. 861-4.
Publication Year :: 2010
Abstract: Two PDE4D gene polymorphisms [SNP41 (rs152312 and SNP87 (rs 2910829)] were studied in patients with acute stroke (n = 577) and in control sample (n = 270). Significant differences in the genotype and allele frequency distribution were found between these samples for polymorphism SNP41. We showed that the AA and AG genotypes of SNP41 polymorphism were associated with higher risk of acute stroke development in the Moscow population (OR = 1.6). No association of SNP87 polymorphism with the disease was observed.

Subjects :: Cyclic Nucleotide Phosphodiesterases, Type 4
Female
Humans
Male
Moscow epidemiology
Risk Factors
Stroke epidemiology
Alleles
Cyclic Nucleotide Phosphodiesterases, Type 3 genetics
Gene Frequency
Polymorphism, Single Nucleotide
Stroke genetics

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