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Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease.
- Source :
-
Upsala journal of medical sciences [Ups J Med Sci] 2010 Nov; Vol. 115 (4), pp. 253-9. Date of Electronic Publication: 2010 Aug 23. - Publication Year :
- 2010
-
Abstract
- Background: Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is an emerging risk factor for atherothrombosis.<br />Aims: The aim of this study was to investigate the levels of MPV in subjects with NAFLD having no confounding factors for atherosclerosis such as obesity, diabetes mellitus, and hypertension. In addition, the possible relationship between MPV and carotid artery intima media thickness (CIMT), a well known marker of subclinical atherosclerosis, was also studied.<br />Methods: MPV and CIMT levels were measured in 60 biopsy-proven NAFLD subjects and 54 healthy controls. Age and sex were similar between two groups.<br />Results: Body mass index and waist circumference levels were higher in the NAFLD group when compared to the controls. There were no differences between the two groups regarding LDL cholesterol levels, whereas HDL cholesterol levels were lower in the NAFLD group. MPV and CIMT levels were not different between the two groups. According to the correlation analyses, CIMT levels were positively correlated to age in patients with NAFLD. However, no significant correlation was found between MPV and CIMT levels.<br />Conclusions: The results of this study do not show any difference in MPV levels between subjects with NAFLD and controls. These finding suggests that in the absence of other metabolic risk factors, MPV might not be involved in the mechanism(s) of increased cardiovascular risk in NAFLD.
- Subjects :
- Adult
Biopsy
Blood Platelets pathology
Case-Control Studies
Fatty Liver blood
Fatty Liver complications
Humans
Insulin metabolism
Liver pathology
Male
Non-alcoholic Fatty Liver Disease
Platelet Activation
Risk
Thrombosis blood
Tunica Intima pathology
Tunica Media pathology
Blood Platelets cytology
Carotid Artery Diseases blood
Carotid Artery Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 2000-1967
- Volume :
- 115
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Upsala journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 20731535
- Full Text :
- https://doi.org/10.3109/03009734.2010.500062