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Sequence analysis of meq oncogene among Polish strains of Marek's disease.
- Source :
-
Polish journal of veterinary sciences [Pol J Vet Sci] 2010; Vol. 13 (2), pp. 263-7. - Publication Year :
- 2010
-
Abstract
- The main goal of the present study was to analyse the nucleotide and amino acid sequence of Meq--the main oncoprotein of Marek's disease virus. The conducted analysis of the nucleotide sequences of MDV has shown a significant similarity between Polish and reference strains of MDV assigned to the vvMDV and vv+MDV pathotypes. Some of the detected nucleotide point mutations were specific only for Polish strains. The sequence analysis has shown a number of single substitutions and two poly-amino acid insertions among strains defined as mild-pathogenic (mMDV) and one attenuated vaccine strain CVI988--Rispens. These results indicate that there is a close relation between changes in nucleotide or amino acid sequence of meq and the virulence of Polish MDV strains.
- Subjects :
- Amino Acid Sequence
Animals
Herpesvirus 2, Gallid classification
Marek Disease epidemiology
Molecular Sequence Data
Oncogene Proteins, Viral chemistry
Oncogene Proteins, Viral genetics
Phylogeny
Poland epidemiology
Poultry
Herpesvirus 2, Gallid genetics
Marek Disease virology
Oncogene Proteins, Viral metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1505-1773
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Polish journal of veterinary sciences
- Publication Type :
- Academic Journal
- Accession number :
- 20731180