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Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 01; Vol. 20 (19), pp. 5891-4. Date of Electronic Publication: 2010 Aug 01. - Publication Year :
- 2010
-
Abstract
- Potent and selective adenosine A(1) receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adenosine A1 Receptor Antagonists chemical synthesis
Adenosine A1 Receptor Antagonists pharmacokinetics
Animals
Pyrazoles chemical synthesis
Pyrazoles pharmacokinetics
Rats
Rats, Wistar
Receptor, Adenosine A1 metabolism
Structure-Activity Relationship
Adenosine A1 Receptor Antagonists chemistry
Pyrazoles chemistry
Receptor, Adenosine A1 chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20728355
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.07.095