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Advanced hip osteoarthritis: magnetic resonance imaging aspects and histopathology correlations.
- Source :
-
Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2010 Nov; Vol. 18 (11), pp. 1429-35. Date of Electronic Publication: 2010 Aug 18. - Publication Year :
- 2010
-
Abstract
- Objectives: To correlate magnetic resonance imaging (MRI) aspects of the femoral head with histological findings in advanced hip osteoarthritis (OA), with special emphasis on bone marrow edema (BME).<br />Methods: MRI was performed in patients with advanced hip OA scheduled for hip arthroplasty. Coronal T1-, fat-suppressed T2-, T1 with gadolinium intravenous injection sequences were obtained on a 1.5 T MR-scanner within 1 month before surgery. Coronal MR images corresponding to the ligamentum teres plane were analyzed by two independent readers blinded to histological data. Normal bone marrow, subchondral cyst, subchondral fracture, edema-like, necrosis-like, and necrosis MR patterns were reported on a synthesis scheme. After surgery, the femoral heads specimens were cut through the ligamentum teres plane and histologically analyzed for correlations.<br />Results: Twenty-three femoral heads were analyzed (female 56.5%, mean age 64.5 years). Edema-like MR pattern was correlated with histological (H) edema (Kappa (K): 0.77). Necrosis-like MR pattern was correlated with H fibrosis (K: 0.49) and with H necrosis (K: 0.24). Cyst MR pattern was correlated with H bone cysts (K: 0.58). Necrosis MR pattern corresponded to a mixture of histological lesions. Sensitivity and specificity of MRI varied from 26% to 80% and from 86% to 95% respectively.<br />Conclusion: In advanced hip OA, the so-called "BME" MR lesion corresponds to a combination of edema, fibrosis, and necrosis at histopathology. When the classical "BME" is more specifically separated into edema-like and necrosis-like MR patterns, MR Imaging and histological findings show substantial agreement, with edema-like MR pattern mainly corresponding to histological edema.<br /> (Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Bone Cysts pathology
Bone Marrow Diseases pathology
Edema pathology
Female
Femur Head Necrosis pathology
Gadolinium
Humans
Male
Middle Aged
Osteoarthritis, Hip diagnostic imaging
Prospective Studies
Radiography
Radioisotopes
Sensitivity and Specificity
Young Adult
Femur Head pathology
Magnetic Resonance Imaging methods
Osteoarthritis, Hip pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-9653
- Volume :
- 18
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Osteoarthritis and cartilage
- Publication Type :
- Academic Journal
- Accession number :
- 20727415
- Full Text :
- https://doi.org/10.1016/j.joca.2010.08.008