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Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Sep 28; Vol. 46 (36), pp. 6822-4. Date of Electronic Publication: 2010 Aug 20. - Publication Year :
- 2010
-
Abstract
- A copper-catalyzed addition of arylboronates to isatins has been developed to give 3-aryl-3-hydroxy-2-oxindoles under mild conditions. The catalytic cycle of this process has been examined through a series of stoichiometric reactions and an effective asymmetric variant has also been described by the use of a chiral N-heterocyclic carbene ligand.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 46
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20725672
- Full Text :
- https://doi.org/10.1039/c0cc01635g