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Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.
- Source :
-
Journal of nucleic acids [J Nucleic Acids] 2010 Jul 25; Vol. 2010. Date of Electronic Publication: 2010 Jul 25. - Publication Year :
- 2010
-
Abstract
- Nicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3). Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan. Nicotinamide is also commercially available in vitamin supplements and in a range of cosmetic, hair, and skin preparations. Nicotinamide is the primary precursor of nicotinamide adenine dinucleotide (NAD(+)), an essential coenzyme in ATP production and the sole substrate of the nuclear enzyme poly-ADP-ribose polymerase-1 (PARP-1). Numerous in vitro and in vivo studies have clearly shown that PARP-1 and NAD(+) status influence cellular responses to genotoxicity which can lead to mutagenesis and cancer formation. This paper will examine the role of nicotinamide in the protection from carcinogenesis, DNA repair, and maintenance of genomic stability.
Details
- Language :
- English
- ISSN :
- 2090-021X
- Volume :
- 2010
- Database :
- MEDLINE
- Journal :
- Journal of nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 20725615
- Full Text :
- https://doi.org/10.4061/2010/157591