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Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients.
- Source :
-
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2010 Jul; Vol. 105 (4), pp. 460-6. - Publication Year :
- 2010
-
Abstract
- Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-gamma, TNF-alpha and TGF-beta, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, gamma-glutamil transferase (gamma-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-alpha (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), gamma-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.
- Subjects :
- Adolescent
Adult
Aged
Analysis of Variance
Case-Control Studies
Hepatitis C complications
Hepatitis C pathology
Humans
Liver Cirrhosis complications
Liver Cirrhosis pathology
Liver Diseases, Parasitic complications
Liver Diseases, Parasitic pathology
Middle Aged
Necrosis pathology
ROC Curve
Schistosomiasis complications
Schistosomiasis pathology
Severity of Illness Index
Splenic Diseases complications
Splenic Diseases pathology
Young Adult
Biomarkers blood
Hepatitis C blood
Liver Cirrhosis blood
Liver Diseases, Parasitic blood
Schistosomiasis blood
Splenic Diseases blood
Subjects
Details
- Language :
- English
- ISSN :
- 1678-8060
- Volume :
- 105
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- 20721491
- Full Text :
- https://doi.org/10.1590/s0074-02762010000400018