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Norterpenoids and related peroxides from the formosan marine sponge Negombata corticata.
- Source :
-
Journal of natural products [J Nat Prod] 2010 Sep 24; Vol. 73 (9), pp. 1538-43. - Publication Year :
- 2010
-
Abstract
- Six norterpenes including negombatoperoxides A and B (4 and 5), the inseparable epimers negombatoperoxides C and D (6 and 7), negombatodiol (8), and negombatolactone (9), in combination with three known compounds, (+)-nuapapuin B (1), (+)-nuapapuin B methyl ester (2), and (+)-aikupikoxide C (3), were isolated from the Formosan marine sponge Negombata corticata. In addition, 6,6-dimethylundecane-2,5,10-trione (10) was isolated for the first time from a natural source. Their structures, including relative configurations, were elucidated on the basis of interpretation of spectroscopic data and by the application of the empirical rule established by Capon and MacLeod. The absolute configurations of 8 and 9 were established by the application of Mosher's method and comparison of CD data with known lactones, respectively. Cytotoxicity of these isolates against human breast carcinoma, human liver carcinoma, and human lung carcinoma cell lines was evaluated.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Circular Dichroism
Drug Screening Assays, Antitumor
Female
Humans
Marine Biology
Molecular Structure
Peroxides chemistry
Peroxides pharmacology
Terpenes chemistry
Terpenes pharmacology
Antineoplastic Agents isolation & purification
Peroxides isolation & purification
Porifera chemistry
Terpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 73
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 20718475
- Full Text :
- https://doi.org/10.1021/np100353x