Back to Search
Start Over
A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Sep 28; Vol. 46 (36), pp. 6747-9. Date of Electronic Publication: 2010 Aug 18. - Publication Year :
- 2010
-
Abstract
- Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.
- Subjects :
- Binding Sites
Cell Adhesion Molecules metabolism
HIV Infections transmission
Humans
Lectins, C-Type metabolism
Receptors, Cell Surface metabolism
Shikimic Acid chemistry
Cell Adhesion Molecules antagonists & inhibitors
Lectins, C-Type antagonists & inhibitors
Receptors, Cell Surface antagonists & inhibitors
Small Molecule Libraries chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 46
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20717628
- Full Text :
- https://doi.org/10.1039/c0cc00830c