Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.

Authors :: Maslennikova AV
Orlova AG
Golubiatnikov GY
Kamensky VA
Shakhova NM
Babaev AA
Snopova LB
Ivanova IP
Plekhanov VI
Prianikova TI
Turchin IV
Source :: Journal of biophotonics [J Biophotonics] 2010 Dec; Vol. 3 (12), pp. 743-51. Date of Electronic Publication: 2010 Aug 16.
Publication Year :: 2010
Abstract: The capabilities of diffuse optical spectroscopy for noninvasive assessing of oxygen status in experimental tumors have been demonstrated. Specific features of the distribution of total hemoglobin, oxygenated hemoglobin, deoxygenated hemoglobin, and blood-oxygen saturation were shown on two tumor models having different histological structure and functional characteristics. The results obtained by the optical technique were verified by immunohistochemical study of tissue samples marked with exogenous marker of hypoxia--pimonidazole.<br /> (Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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