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Reductions in skin and systemic parasite burdens as a combined effect of topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) amazonensis.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2010 Nov; Vol. 54 (11), pp. 4699-704. Date of Electronic Publication: 2010 Aug 16. - Publication Year :
- 2010
-
Abstract
- This study aimed to investigate the activity of a combination of topical paromomycin gel and oral miltefosine for the treatment of experimental cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. The efficacy of the combination, evaluated by measuring lesion size and parasite burden in the skin and spleen, was assessed in BALB/c mice infected by L. (L.) amazonensis. The miltefosine was administered orally at 10 mg/kg of body weight/day for 10 days, while 10% paromomycin gel was applied topically twice a day for 20 days. Treatment of the experimentally infected animals with a topical paromomycin-oral miltefosine combination induced a statistically significant reduction in lesion size and parasite burden in the skin and spleen, with complete healing of ulcers, compared with those treated with a placebo group. A combination of topical paromomycin gel and oral miltefosine provided enhanced efficacy in the treatment of L. (L.) amazonensis-infected mice, showing activity higher than that observed for the monotherapeutic regimens.
- Subjects :
- Administration, Oral
Administration, Topical
Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents pharmacology
Antiprotozoal Agents administration & dosage
Antiprotozoal Agents pharmacology
Female
Leishmaniasis parasitology
Mice
Mice, Inbred BALB C
Paromomycin administration & dosage
Paromomycin pharmacology
Phosphorylcholine administration & dosage
Phosphorylcholine pharmacology
Phosphorylcholine therapeutic use
Anti-Bacterial Agents therapeutic use
Antiprotozoal Agents therapeutic use
Leishmania drug effects
Leishmaniasis drug therapy
Paromomycin therapeutic use
Phosphorylcholine analogs & derivatives
Skin physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 54
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 20713665
- Full Text :
- https://doi.org/10.1128/AAC.00809-10