Back to Search
Start Over
The risk of arrhythmias following coronary artery bypass surgery: do smokers have a paradox effect?
- Source :
-
Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2010 Nov; Vol. 11 (5), pp. 550-5. Date of Electronic Publication: 2010 Aug 16. - Publication Year :
- 2010
-
Abstract
- Smoking is reported to increase the risk of arrhythmias. However, there are limited data on its effects on arrhythmias following coronary artery bypass graft (CABG). This is a retrospective review of a prospective database of all CABG patients over an eight-year period. Our cohort (n=2813) was subdivided into: current (n=1169), former (n=837), and non-smokers (n=807). Predictors of arrhythmias following CABG in relation to smoking status were analysed. Atrial arrhythmias occurred in 942 patients (33%). Ventricular arrhythmias occurred in 48 patients (2%) and high-grade atrioventricular block occurred in five patients (0.2%). Arrhythmias were lower in current smokers than former and non-smokers (29% vs. 40% vs. 39%, respectively P<0.001). Logistic regression analysis showed 30% arrhythmia risk reduction in smokers compared to non-smokers [odds ratio (OR) 0.7, 95% confidence intervals (CI) 0.5-0.8] and this effect persisted after accounting for potential confounders while former smokers had the same risk as non-smokers (OR 1.04, CI 0.9-1.3). There were no significant differences in mortality. Smokers are less prone to develop arrhythmias following CABG. This paradox effect is lost in former smokers. This effect is possibly due to a lower state of hyper adrenergic stimulation observed in smokers than non-smokers following the stress of surgery.
- Subjects :
- Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac mortality
Arrhythmias, Cardiac prevention & control
Chi-Square Distribution
Coronary Artery Bypass mortality
Databases as Topic
Female
Humans
Ireland epidemiology
Logistic Models
Male
Middle Aged
Odds Ratio
Retrospective Studies
Risk Assessment
Risk Factors
Smoking mortality
Time Factors
Treatment Outcome
Arrhythmias, Cardiac etiology
Coronary Artery Bypass adverse effects
Smoking adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1569-9285
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Interactive cardiovascular and thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 20713536
- Full Text :
- https://doi.org/10.1510/icvts.2010.242586