Back to Search
Start Over
Claudin-5-positive angioleiomyoma in the uterus of a degu (Octodon degus ).
- Source :
-
Acta veterinaria Hungarica [Acta Vet Hung] 2010 Sep; Vol. 58 (3), pp. 331-40. - Publication Year :
- 2010
-
Abstract
- A 5-year-old female degu (Octodon degus ) showed the clinical sign of metrorrhagia. During ovariohysterectomy a circumscribed tumoural lesion was found in the right uterine horn. The histopathological diagnosis of this soft tissue mass was primary benign cavernous angioleiomyoma of the uterus. During immunohistochemical analysis the neoplastic endothelial cells of this mixed mesenchymal tumour showed strong membrane positivity for the endothelial marker claudin-5 but were negative for CD31 (another endothelial marker). The endothelial cells of the internal positive control tissues such as intact peritumoural vessels were positive for claudin-5 but negative for the CD31 endothelial marker. As it has been described also in other species, it seems that claudin-5 is a better endothelial marker than CD31 for the detection of normal and neoplastic endothelial cells in different tissues of degus.
- Subjects :
- Angiomyoma metabolism
Angiomyoma pathology
Animals
Female
Gene Expression Regulation, Neoplastic physiology
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Rodent Diseases metabolism
Rodent Diseases surgery
Uterine Neoplasms metabolism
Uterine Neoplasms pathology
Angiomyoma veterinary
Biomarkers, Tumor metabolism
Membrane Proteins metabolism
Octodon
Rodent Diseases pathology
Uterine Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0236-6290
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta veterinaria Hungarica
- Publication Type :
- Academic Journal
- Accession number :
- 20713324
- Full Text :
- https://doi.org/10.1556/AVet.58.2010.3.6