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Early-life stress and neurometabolites of the hippocampus.
- Source :
-
Brain research [Brain Res] 2010 Oct 28; Vol. 1358, pp. 191-9. Date of Electronic Publication: 2010 Aug 14. - Publication Year :
- 2010
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Abstract
- We tested the hypothesis that early life stress would persistently compromise neuronal viability of the hippocampus of the grown nonhuman primate. Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid considered reflective of neuronal density/functional integrity-using in vivo proton magnetic resonance spectroscopic imaging (MRSI). The subjects reported herein represent a re-analysis of a sample of nineteen adult male bonnet macaques that had been reared in infancy under induced stress by maternal variable foraging demand (VFD) (N=10) or control rearing conditions (N=9). The MRSI spectral readings were recorded using a GE 1.5 Tesla machine under anesthesia. Relative NAA values were derived using NAA as numerator and both choline (Cho) or creatine (Cr) as denominators. Left medial temporal lobe (MTL) NAA/Cho but not NAA/Cr was decreased in VFD subjects versus controls. An MTL NAA/Cho ratio deficit remained significant when controlling for multiple confounding variables. Regression analyses suggested that the NAA/Choline finding was due to independently low left NAA and high left choline. Right MTL showed no rearing effects for NAA, but right NAA was positively related to body mass, irrespective of denominator. The current data indicate that decreased left MTL NAA/Cho may reflect low neuronal viability of the hippocampus following early life stress in VFD-reared versus normally-reared subjects. Given the importance of the hippocampus in stress-mediated toxicity, validation of these data using absolute quantification is suggested and correlative neurohistological studies of hippocampus are warranted.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Aspartic Acid metabolism
Creatine metabolism
Functional Laterality
Macaca mulatta
Magnetic Resonance Spectroscopy methods
Male
Maternal Deprivation
Regression Analysis
Spectrum Analysis
Stress, Psychological metabolism
Aspartic Acid analogs & derivatives
Choline metabolism
Hippocampus metabolism
Stress, Psychological pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1358
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 20713023
- Full Text :
- https://doi.org/10.1016/j.brainres.2010.08.021