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Effects of intracoronary administration of contrast media on coronary hemodynamics in a canine post ischemic reperfusion model.
- Source :
-
Catheterization and cardiovascular diagnosis [Cathet Cardiovasc Diagn] 1991 Jun; Vol. 23 (2), pp. 144-49. - Publication Year :
- 1991
-
Abstract
- Hemodynamic changes due to intracoronary injections of nonionic contrast medium Omnipaque-350 (OM), ionic dimer Hexabrix (HB), and ionic contrast medium Renografin-76 (R76) were compared at baseline and during reperfusion after a 30-minute left anterior descending coronary artery (LAD) occlusion. In 11 open chest, anesthetized, and atrially paced dogs, 4 ml of either OM, HB, R76, or 0.9% NaCl were injected into the carotid-LAD bypass system. Coronary blood flow (CBF) and coronary vascular resistance (CVR) were measured before, during and after the intracoronary injection. The maximal hyperemic change (in percentage) from the preinjection value of CBF and CVR were calculated. The results at baseline and during reperfusion for CBF were: 104 +/- 14% vs. 85 +/- 10% for OM (NS); 76 +/- 11% vs. 39 +/- 9% for R76 (p less than 0.05); 57 +/- 8% vs. 33 +/- 5% for HB (P less than 0.05); and 30 +/- 7% vs. 9 +/- 4% for 0.9% NaCl (p less than 0.05). Consequently, the hyperemic changes of CVR at baseline and during reperfusion were: -49 +/- 3 vs. -42 +/- 4% for OM (NS); -44 +/- 3% vs. -24 +/- 6% for R76 (p less than 0.01); -36 +/- 3% vs. -24 +/- 4% for HB (p less than 0.05); and -18 +/- 4% vs. -7 +/- 3% for 0.9% NaCl (p less than 0.05). Thus, ischemia and reperfusion significantly dampened the coronary hemodynamic and vascular response to R76, HB, and 0.9% NaCl but not to OM. The preserved coronary vascular reserve with high flow in this canine post-ischemic reperfusion model may explain the advantage of nonionic over ionic contrast media used in emergency coronary angiography following thrombolysis.
- Subjects :
- Animals
Contrast Media administration & dosage
Coronary Vessels
Diatrizoate Meglumine administration & dosage
Diatrizoate Meglumine pharmacology
Dogs
Hemodynamics drug effects
Injections, Intra-Arterial
Iohexol administration & dosage
Iohexol pharmacology
Ioxaglic Acid administration & dosage
Ioxaglic Acid pharmacology
Vascular Resistance drug effects
Contrast Media pharmacology
Coronary Circulation drug effects
Myocardial Reperfusion
Subjects
Details
- Language :
- English
- ISSN :
- 0098-6569
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Catheterization and cardiovascular diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 2070405
- Full Text :
- https://doi.org/10.1002/ccd.1810230220