Back to Search
Start Over
Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
- Source :
-
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2011 Feb; Vol. 22 (1-2), pp. 55-65. Date of Electronic Publication: 2010 Aug 11. - Publication Year :
- 2011
-
Abstract
- The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Details
- Language :
- English
- ISSN :
- 1432-1777
- Volume :
- 22
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Mammalian genome : official journal of the International Mammalian Genome Society
- Publication Type :
- Academic Journal
- Accession number :
- 20700596
- Full Text :
- https://doi.org/10.1007/s00335-010-9277-3