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Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2011 Jan; Vol. 25 (1), pp. 16-24. Date of Electronic Publication: 2010 Aug 08. - Publication Year :
- 2011
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Abstract
- Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy young men slept for a 2-h night followed by either a standard 8-h recovery night (n=12), a 30-min nap (at 1 p.m.) in addition to an 8-h recovery night (n=10), or a 10-h extended recovery night (n=9). A control group slept 3 consecutive 8-h nights (n=9). Subjects underwent continuous electroencephalogram polysomnography and blood was sampled every day at 7 a.m. Leukocytes, inflammatory and atherogenesis biomarkers (high-sensitivity C-reactive protein, interleukin-8, myeloperoxidase, fibrinogen and apolipoproteins ApoB/ApoA), sleep patterns and sleepiness were investigated. All parameters remained unchanged in the control group. After sleep restriction, leukocyte and - among leukocyte subsets - neutrophil counts were increased, an effect that persisted after the 8-h recovery sleep, but, in subjects who had a nap or a 10-h recovery sleep, these values returned nearly to baseline. Inflammatory and atherogenesis biomarkers were unchanged except for higher myeloperoxidase levels after sleep restriction. The increased sleepiness after sleep restriction was reversed better in the nap and extended sleep recovery conditions. Saliva cortisol decreased immediately after the nap. Our results indicate that additional recovery sleep after sleep restriction provided by a midday nap prior to recovery sleep or a sleep extended night can improve alertness and return leukocyte counts to baseline values.<br /> (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Atherosclerosis immunology
Data Interpretation, Statistical
Female
Humans
Hydrocortisone metabolism
Inflammation immunology
Leukocyte Count
Male
Neutrophils physiology
Peroxidase metabolism
Polysomnography
Saliva metabolism
Software
Young Adult
Attention physiology
Immunity, Cellular physiology
Sleep immunology
Sleep Deprivation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2139
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 20699115
- Full Text :
- https://doi.org/10.1016/j.bbi.2010.08.001