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[Gestagens and the brain].
- Source :
-
Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 2010 (6), pp. 40-9. - Publication Year :
- 2010
-
Abstract
- Modern data on molecular mechanisms underlying intracerebral pleutropic action ofgestagens (progesterone, its metabolites, and synthetic gestagens) are reviewed. Properties of classical and membrane-bound progesterone receptors involved in regulation of gene expression, modulation of neurotransmitter systems, and activation of signal cascades in neurons are described along with data of regional distribution of progesterone receptor subtypes in brain, metabolism, functional activity, and mechanisms of action of progesterone metabolites. Special attention is given to analysis of progesterone and metabolite neuroprotective activity in CNS, such as anti-inflammatory and antiapoptotic effects, and participation in neurogenesis regulation. Clinical application of progesterone-based drugs is discussed with reference to the treatment of brain injuries and prospects for extension of indications for their use in neurologic practice.
- Subjects :
- Animals
Apoptosis
Brain blood supply
Brain Injuries drug therapy
Humans
Neurogenesis
Neuroglia physiology
Neurons physiology
Neuroprotective Agents pharmacology
Neuroprotective Agents therapeutic use
Neurotransmitter Agents metabolism
Progestins pharmacology
Receptors, Progesterone metabolism
Brain physiology
Progestins physiology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-6047
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Vestnik Rossiiskoi akademii meditsinskikh nauk
- Publication Type :
- Academic Journal
- Accession number :
- 20698305