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Disodium-fosfomycin pharmacokinetics and bioavailability in post weaning piglets.
- Source :
-
Research in veterinary science [Res Vet Sci] 2011 Jun; Vol. 90 (3), pp. 498-502. Date of Electronic Publication: 2010 Aug 08. - Publication Year :
- 2011
-
Abstract
- Disodium-fosfomycin pharmacokinetics has been studied in different species after oral, intravenous, intramuscular and subcutaneous administration. At present there are neither documented clinical experiences of the use of fosfomycin in pigs nor any published studies in weaning piglets, although it is a period of high incidence of infectious diseases. The pharmacokinetics and the bioavailability of sodium fosfomycin were studied in post weaning piglets after intravenous and intramuscular administration of 15 mg/kg of body weight. Plasma concentrations were measured by a high-performance liquid ms/ms. After IV administration the area under the fosfomycin concentration:time curve in plasma was AUC(0-12) of 120.00 ± 23.12 μg h/ml and the volume of distribution (Vd) of 273.00 ± 40.70 ml/kg. The elimination was rapid with a plasma clearance of 131.50 ± 30.07 ml/kg/h and a T(1/2) of 1.54 ± 0.40 h. Peak serum concentration (Cmax), Tmax, AUC(0-12) and bioavailability for the IM administration were 43.00 ± 4.10 μg/ml, 0.75 ± 0.00 h, 99.00 ± 0.70 μg h/ml and 85.5 ± 9.90% respectively. Different authors have determined a minimum inhibitory concentration (MIC90) ranging from 0.25 μg/ml for Streptococcus sp. and 0.5 μg/ml for Escherichia coli. Considering the above, and according to the values of plasma concentration vs time profiles observed in this study, effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following IV and IM administration of 15 mg/kg in piglets.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Animals, Newborn metabolism
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents blood
Biological Availability
Chromatography, High Pressure Liquid veterinary
Female
Fosfomycin administration & dosage
Fosfomycin blood
Injections, Intramuscular veterinary
Injections, Intravenous veterinary
Male
Swine
Weaning
Anti-Bacterial Agents pharmacology
Fosfomycin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2661
- Volume :
- 90
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Research in veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 20696447
- Full Text :
- https://doi.org/10.1016/j.rvsc.2010.07.011