Actin-based motility of Burkholderia thailandensis requires a central acidic domain of BimA that recruits and activates the cellular Arp2/3 complex.

Authors :: Sitthidet C
Stevens JM
Field TR
Layton AN
Korbsrisate S
Stevens MP
Source :: Journal of bacteriology [J Bacteriol] 2010 Oct; Vol. 192 (19), pp. 5249-52. Date of Electronic Publication: 2010 Aug 06.
Publication Year :: 2010
Abstract: Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.

Subjects :: Bacterial Proteins genetics
Burkholderia genetics
Electrophoresis, Polyacrylamide Gel
Microfilament Proteins genetics
Microscopy, Confocal
Actins metabolism
Bacterial Proteins metabolism
Burkholderia metabolism
Microfilament Proteins metabolism

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