Back to Search
Start Over
Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection.
- Source :
-
Postgraduate medical journal [Postgrad Med J] 2010 Sep; Vol. 86 (1019), pp. 515-21. Date of Electronic Publication: 2010 Aug 05. - Publication Year :
- 2010
-
Abstract
- Purpose of Study: The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection.<br />Study Design: The clinical and microbiological data of hospitalised adult patients admitted between 29 June and 28 October 2009, with pandemic A (H1N1) 2009 or seasonal influenza A infection, were analysed.<br />Results: A total of 186 patients including 69 pandemic A (H1N1) and 117 seasonal influenza were analysed. The majority (75%) under 50 years of age had pandemic A (H1N1). Compared with seasonal influenza, pandemic A (H1N1) patients were younger (median age 47 years vs 76 years, p<0.001), less likely to have lower respiratory tract symptoms (46.4% vs 66.7%, p=0.007), but more likely to be obese (5.8% vs 0%, p=0.018), pregnant (7.2% vs 0.9%, p=0.027) or have no underlying predisposing factors (24.6% vs 5.1%, p<0.001). Patients with pandemic A (H1N1) were more likely to receive oseltamivir (91.3% vs 40.2%, p<0.001), but less likely to receive antibiotics (75.4% vs 90.6%, p=0.005). Respiratory failure was the reason for intensive care unit admission for all four patients with pandemic A (H1N1), but only for one of three patients with seasonal influenza. There were no statistical significant differences in the rate of intensive care unit admission or death.<br />Conclusions: In addition to age, several clinical parameters were different between pandemic A (H1N1) and seasonal influenza. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Antiviral Agents therapeutic use
Disease Outbreaks
Female
Humans
Influenza, Human drug therapy
Male
Middle Aged
Obesity epidemiology
Oseltamivir therapeutic use
Pregnancy
Retrospective Studies
Seasons
Treatment Outcome
Young Adult
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza A virus isolation & purification
Influenza, Human diagnosis
Influenza, Human epidemiology
Obesity complications
Pregnancy Complications, Infectious epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-0756
- Volume :
- 86
- Issue :
- 1019
- Database :
- MEDLINE
- Journal :
- Postgraduate medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 20693151
- Full Text :
- https://doi.org/10.1136/pgmj.2009.096206