Effects of N,N-dimethylformamide and its degradation products in zebrafish embryos.

Authors :: Groth G
Kronauer K
Freundt KJ
Source :: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 1994 Jun; Vol. 8 (3), pp. 401-6.
Publication Year :: 1994
Abstract: The response of zebrafish (Brachydanio rerio) embryos, cultured in reconstituted water, to continuous treatment with N,N-dimethylformamide (DMF) or its degradation products until hatching, was investigated. The embryos were distinctly susceptible to DMF, N-(hydroxymethyl)-N-methylformamide (DMF-OH), N-methylformamide (NMF), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and formamide (FA). Concentrations of 18 (DMF-OH), 121 (DMF), 163 (AMCC), 186 (NMF) and 203 (FA) mmol/litre produced 50% embryo lethality (LC(50)). Only treatment with DMF, NMF or FA induced malformations, involving curvature of the spine and tail and reduction of heart size and action with decreased blood circulation.

Language :: English
ISSN :: 0887-2333
Volume :: 8
Issue :: 3
Database :: MEDLINE
Journal :: Toxicology in vitro : an international journal published in association with BIBRA
Publication Type :: Academic Journal
Accession number :: 20692931
Full Text :: https://doi.org/10.1016/0887-2333(94)90161-9

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