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Wavelength dependency for UVA-induced suppression of recall immunity in humans.
- Source :
-
Journal of dermatological science [J Dermatol Sci] 2010 Sep; Vol. 59 (3), pp. 192-7. Date of Electronic Publication: 2010 Aug 09. - Publication Year :
- 2010
-
Abstract
- Background: Ultraviolet (UV) A radiation, which has both mutagenic and immune suppressive effects on the skin, is increasingly recognised as a key contributor to cutaneous carcinogenesis. Whilst short wavelength UVB (290-320 nm) is well-recognised as an environmental health hazard, the dangers of UVA (320-400 nm) are relatively unexplored.<br />Objective: Using the nickel model of recall immunity in healthy human volunteers, we determined the wavelength dependency for UV-induced immunosuppression across the UVA spectrum.<br />Methods: Dose-response curves were established for local suppression of contact hypersensitivity responses to nickel at 7 wavelengths between 331 and 392 nm.<br />Results: We found a broad peak of UVA immune suppressive effectiveness at 364-385 nm. Whilst we had previously found linear dose-responses for UVB-induced immunosuppression in this model, long wavelength UVA caused bell-shaped, Gaussian dose-responses, suggesting different chromophores and mechanisms of immunosuppression for UVB and UVA.<br />Conclusion: The immunosuppressive peak induced by longwave UVA has not been described previously for any species and being close to the border with visible light indicates an unexpected role for these long wavebands in human health and disease.<br /> (Copyright 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Dermatitis, Allergic Contact etiology
Dermatitis, Allergic Contact immunology
Dose-Response Relationship, Radiation
Female
Humans
Middle Aged
Skin drug effects
Skin immunology
Dermatitis, Allergic Contact radiotherapy
Immune Tolerance radiation effects
Immunosuppression Therapy
Nickel toxicity
Skin radiation effects
Ultraviolet Rays
Subjects
Details
- Language :
- English
- ISSN :
- 1873-569X
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of dermatological science
- Publication Type :
- Academic Journal
- Accession number :
- 20691571
- Full Text :
- https://doi.org/10.1016/j.jdermsci.2010.07.005