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Natalizumab (Tysabri).
- Source :
-
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2010 Oct; Vol. 31 (9), pp. 1588-90. Date of Electronic Publication: 2010 Aug 05. - Publication Year :
- 2010
-
Abstract
- Natalizumab is a humanized IgG4κ monoclonal antibody that is a selective adhesion molecule inhibitor, which prevents adhesion of leukocytes to endothelial cells. It is the first monoclonal antibody approved by the FDA for the treatment of relapsing-remitting MS. This article will review the mechanism of action and clinical role of this agent.
- Subjects :
- Animals
Antibodies, Monoclonal, Humanized
Brain drug effects
Cell Adhesion drug effects
Cell Adhesion immunology
Cell Migration Inhibition drug effects
Cell Migration Inhibition immunology
Humans
Leukocytes drug effects
Models, Immunological
Natalizumab
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal immunology
Brain immunology
Leukocytes immunology
Multiple Sclerosis drug therapy
Multiple Sclerosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1936-959X
- Volume :
- 31
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- AJNR. American journal of neuroradiology
- Publication Type :
- Academic Journal
- Accession number :
- 20688889
- Full Text :
- https://doi.org/10.3174/ajnr.A2226