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Hypoxic tumors and their effect on immune cells and cancer therapy.

Authors :
Yotnda P
Wu D
Swanson AM
Source :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2010; Vol. 651, pp. 1-29.
Publication Year :
2010

Abstract

The abnormal decrease or the lack of oxygen supply to cells and tissues is called hypoxia. This condition is commonly seen in various diseases such as rheumatoid arthritis and atherosclerosis, also in solid cancers. Pre-clinical and clinical studies have shown that hypoxic cancers are extremely aggressive, resistant to standard therapies (chemotherapy and radiotherapy), and thus very difficult to eradicate. Hypoxia affects both the tumor and the immune cells via various pathways. This review summarizes the most common effects of hypoxia on immune cells that play a key role in the anti-tumor response, the limitation of current therapies, and the potential solutions that were developed for hypoxic malignancies.

Details

Language :
English
ISSN :
1940-6029
Volume :
651
Database :
MEDLINE
Journal :
Methods in molecular biology (Clifton, N.J.)
Publication Type :
Academic Journal
Accession number :
20686957
Full Text :
https://doi.org/10.1007/978-1-60761-786-0_1