Back to Search
Start Over
Deciphering the complexity of Toll-like receptor signaling.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2010 Dec; Vol. 67 (24), pp. 4109-34. Date of Electronic Publication: 2010 Jul 31. - Publication Year :
- 2010
-
Abstract
- Toll-like receptors (TLRs) are essential players in the innate immune response to invading pathogens. Although extensive research efforts have provided a considerable wealth of information on how TLRs function, substantial gaps in our knowledge still prevent the definition of a complete picture of TLR signaling. However, several recent studies describe additional layers of complexity in the regulation of TLR ligand recognition, adaptor recruitment, posttranslational modifications of signaling proteins, and the newly described, autonomous role of the TLR4 co-receptor CD14. In this review, by using it as model system for the whole TLR family, we attempt to provide a complete description of the signal transduction pathways triggered by TLR4, with a particular emphasis on the molecular and cell biological aspects regulating its function. Finally, we discuss a recently reported model of CD14-dependent signaling and highlight its biological implications.
- Subjects :
- Adaptor Proteins, Vesicular Transport genetics
Adaptor Proteins, Vesicular Transport metabolism
Animals
Humans
Interferon Regulatory Factor-3 genetics
Interferon Regulatory Factor-3 metabolism
Lipopolysaccharide Receptors immunology
Lipopolysaccharides chemistry
Lipopolysaccharides immunology
Lymphocyte Antigen 96 chemistry
Lymphocyte Antigen 96 immunology
Myeloid Differentiation Factor 88 genetics
Myeloid Differentiation Factor 88 metabolism
Toll-Like Receptors genetics
Signal Transduction physiology
Toll-Like Receptors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 67
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 20680392
- Full Text :
- https://doi.org/10.1007/s00018-010-0464-x