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The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.
- Source :
-
Nature immunology [Nat Immunol] 2010 Sep; Vol. 11 (9), pp. 854-61. Date of Electronic Publication: 2010 Aug 01. - Publication Year :
- 2010
-
Abstract
- Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease. The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the development of these cells remain unclear. Here we show that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), which was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells. After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21 promoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmune encephalomyelitis. Manipulating AhR signaling could therefore be beneficial in the resolution of excessive inflammatory responses.
- Subjects :
- Animals
Cell Differentiation drug effects
Cell Line, Tumor
Cells, Cultured
Interleukins pharmacology
Mice
Mice, Inbred C57BL
T-Lymphocytes, Regulatory drug effects
Cell Differentiation immunology
Gene Expression Regulation
Oncogene Protein v-maf immunology
Receptors, Aryl Hydrocarbon immunology
T-Lymphocytes, Regulatory cytology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 11
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20676095
- Full Text :
- https://doi.org/10.1038/ni.1912