Back to Search
Start Over
Evaluation of depression risk in LGI1 mutation carriers.
- Source :
-
Epilepsia [Epilepsia] 2010 Sep; Vol. 51 (9), pp. 1685-90. Date of Electronic Publication: 2010 Jul 26. - Publication Year :
- 2010
-
Abstract
- Purpose: Depression is the most common comorbid condition in epilepsy. The cause of this comorbidity is unknown, and could involve psychosocial consequences of epilepsy, treatment side effects, seizure manifestations, or common neurobiologic mechanisms. One hypothesis of particular interest is a shared genetic susceptibility to epilepsy and depression. We tested this hypothesis by studying depressive symptoms in families with an identified genetic form of epilepsy: autosomal dominant partial epilepsy with auditory features caused by mutations in the leucine-rich, glioma inactivated 1 gene (LGI1).<br />Methods: A standardized depression screen was administered to 94 individuals from 11 families with mutations in LGI1, including 38 mutation carriers with epilepsy (AC), 11 clinically unaffected mutation carriers (UC), and 45 noncarriers (NC).<br />Results: Current depressive symptom scores were significantly higher in AC than in NC, an association that remained after excluding depressive symptoms that appeared likely to be caused by antiepileptic medication use. However, scores did not differ between UC and NC.<br />Discussion: Although LGI1 mutation carriers who were clinically affected with epilepsy had increased depressive symptoms, mutation carriers without epilepsy did not. These findings suggest that the increase in depressive symptoms in affected individuals from these families is related to epilepsy or its treatment rather than to LGI1 mutations per se.
- Subjects :
- Adult
Age of Onset
Comorbidity
Depressive Disorder, Major diagnosis
Depressive Disorder, Major genetics
Epilepsies, Partial diagnosis
Epilepsies, Partial epidemiology
Epilepsies, Partial genetics
Epilepsy diagnosis
Epilepsy epidemiology
Female
Health Status
Humans
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Pedigree
Risk Factors
Severity of Illness Index
Surveys and Questionnaires
Depressive Disorder, Major epidemiology
Epilepsy genetics
Heterozygote
Mutation genetics
Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1167
- Volume :
- 51
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Epilepsia
- Publication Type :
- Academic Journal
- Accession number :
- 20659151
- Full Text :
- https://doi.org/10.1111/j.1528-1167.2010.02677.x