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Modulation of arterial pressure by P2 purinoceptors in the paraventricular nucleus of the hypothalamus of awake rats.
- Source :
-
Autonomic neuroscience : basic & clinical [Auton Neurosci] 2010 Dec 08; Vol. 158 (1-2), pp. 79-85. Date of Electronic Publication: 2010 Jul 23. - Publication Year :
- 2010
-
Abstract
- In the present study we evaluated the role of purinergic mechanisms in the PVN on the tonic modulation of the autonomic function to the cardiovascular system as well on the cardiovascular responses to peripheral chemoreflex activation in awake rats. Guide-cannulae were bilaterally implanted in the direction of the PVN of male Wistar rats. Femoral artery and vein were catheterized one day before the experiments. Chemoreflex was activated with KCN (80 μg/0.05 ml, i.v.) before and after microinjections of P2 receptors antagonist into the PVN. Microinjection of PPADS, a non selective P2X antagonist, into the PVN (n=6) produced a significant increase in the baseline MAP (99±2 vs 112±3 mmHg) and HR (332±8 vs 375±8 bpm) but had no effect on the pressor and bradycardic responses to chemoreflex activation. Intravenous injection of vasopressin receptors antagonist after microinjection of PPADS into the PVN produced no effect on the increased baseline MAP. Simultaneous microinjection of PPADS and KYN into the PVN (n=6) had no effect in the baseline MAP, HR or in the pressor and bradycardic responses to chemoreflex activation. We conclude that P2 purinoceptors in the PVN are involved in the modulation of baseline autonomic function to the cardiovascular system but not in the cardiovascular responses to chemoreflex activation in awake rats.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Autonomic Pathways drug effects
Blood Pressure drug effects
Enzyme Inhibitors pharmacology
Male
Microinjections methods
Neurons drug effects
Paraventricular Hypothalamic Nucleus anatomy & histology
Paraventricular Hypothalamic Nucleus drug effects
Potassium Cyanide pharmacology
Purinergic P2X Receptor Antagonists pharmacology
Rats
Rats, Wistar
Receptors, Purinergic P2 drug effects
Wakefulness physiology
Autonomic Pathways physiology
Blood Pressure physiology
Neurons physiology
Paraventricular Hypothalamic Nucleus physiology
Receptors, Purinergic P2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7484
- Volume :
- 158
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Autonomic neuroscience : basic & clinical
- Publication Type :
- Academic Journal
- Accession number :
- 20655811
- Full Text :
- https://doi.org/10.1016/j.autneu.2010.06.012