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[Quantitative evaluation of SPECT with FP-CIT. Importance of the reference area].
- Source :
-
Revista espanola de medicina nuclear [Rev Esp Med Nucl] 2010 Sep-Oct; Vol. 29 (5), pp. 246-50. Date of Electronic Publication: 2010 Jul 23. - Publication Year :
- 2010
-
Abstract
- Objective: The aim of this study is to compare several uptake indexes between specific and non-specific activity to determine the existence of degenerative Parkinsonism according to different reference areas.<br />Material and Methods: A total of 46 patients (23 men and 23 women), randomly selected from individuals referred to our center with a movement disorder, were included in the study. Mean age was 70.2 ± 10.2 years (41-87). The uptake indexes were obtained through the areas of interest (ROIs) located in the striate (specific uptake) and other reference ROIs located in areas with different concentrations of serotonin receptors: low-cerebellum, medium-occipital cortex and high-midbrain.<br />Results: A high linear correlation was found between indexes having low and medium concentration of serotonin receptors. The ROC curve analysis shows an area under the curve of 0.874, 0.886 and 0.739 and regression coefficients of 5.41, 6.62 and 3.41, respectively for the striatum/cerebellum (E/C), striatum/occipital (E/O) and striatum midbrain (E/M) indexes. Optimal cutoff for E/O (1.35), index with the best behavior, provides a sensitivity of 0.84 and specificity of 0.89.<br />Conclusion: The reference area selected may alter the predictive power of the different indexes to determine the existence of a degenerative Parkinsonism.<br /> (Copyright © 2010 Elsevier España, S.L. y SEMNIM. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cerebellum chemistry
Cerebellum diagnostic imaging
Corpus Striatum chemistry
Female
Humans
Male
Mesencephalon chemistry
Middle Aged
Nerve Degeneration diagnostic imaging
Organ Specificity
Parkinson Disease diagnostic imaging
Parkinson Disease, Secondary diagnostic imaging
Predictive Value of Tests
ROC Curve
Receptors, Serotonin analysis
Retrospective Studies
Sampling Studies
Sensitivity and Specificity
Tissue Distribution
Brain diagnostic imaging
Carbon Radioisotopes pharmacokinetics
Iodine Radioisotopes pharmacokinetics
Parkinsonian Disorders diagnostic imaging
Radiopharmaceuticals pharmacokinetics
Tomography, Emission-Computed, Single-Photon
Tropanes pharmacokinetics
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0212-6982
- Volume :
- 29
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear
- Publication Type :
- Academic Journal
- Accession number :
- 20655624
- Full Text :
- https://doi.org/10.1016/j.remn.2010.03.006